[1]李文桂,陈雅棠.载体介导的布鲁氏菌疫苗的研制现状[J].国外医学医学地理杂志,2019,(02):97-104.[doi:10.3969/j.issn.1001-8883.2019.02.001]
 LI Wengui,CHEN Yatang.The statusin the research of vaccine of Brucella mediated by vectors[J].Foreign Medical Sciences (Section of Medgeography),2019,(02):97-104.[doi:10.3969/j.issn.1001-8883.2019.02.001]
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载体介导的布鲁氏菌疫苗的研制现状()
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国外医学医学地理杂志[ISSN:1001-8883/CN:61-1102/R]

卷:
期数:
2019年02期
页码:
97-104
栏目:
专家论坛
出版日期:
2019-07-02

文章信息/Info

Title:
The statusin the research of vaccine of Brucella mediated by vectors
作者:
李文桂陈雅棠
(重庆医科大学附属第一医院传染病寄生虫病研究所,重庆 400016)
Author(s):
LI WenguiCHEN Yatang
(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)
关键词:
布鲁氏菌 OMP蛋白 SOD抗原 L7/L12抗原 疫苗
Keywords:
Brucella OMP antigen SOD antigen L7/L12 antigen vaccine
分类号:
S852.61; R392.11
DOI:
10.3969/j.issn.1001-8883.2019.02.001
文献标志码:
A
摘要:
布鲁氏菌引起的布鲁氏菌病是一种严重危害人畜健康的传染性疾病,采用疫苗防治该菌是当前研究的热点领域之一。OMP、SOD和L7/L12抗原是3 种有效的疫苗候选分子,本文综述了鼠伤寒沙门氏菌、乳酸乳球菌、卡介苗、人赭菌、根癌农杆菌、大肠埃希菌、小肠结肠耶尔森菌、毕赤酵母、禽流感病毒、Semliki森林病毒、山羊痘病毒、牛痘病毒、腺病毒血清型5、伪狂犬病毒和昆虫杆状病毒等载体介导的布鲁氏菌疫苗的研制现状。
Abstract:
Brucellosis caused by Brucella is one type of infectious diseases seriously endandering human and animal health,it recently becomes highlight to control this bacteria by use of the vaccine.OMP,SOD and L7/L12 antigen are 3 types of effective candidate molecules of vaccine,the review outlines the status in the research of vaccine of Brucella mediated by bacteria such as Salmonella typhimurium,Lactococcus lactis,Bacille calmette-Guerin,Ochrobactrum anthropi,Agrobacterium tumefacies,Escherichia coli,Yersinia enterocolitica,and Pichia pastoris,viruses such as Avian Influenza Virus,Semliki forest virus,Goat poxvirus,Vaccinia virus,Adenovirus serotype 5,Pseudorabies Virus,and Baculovirus.

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备注/Memo

备注/Memo:
收稿日期:2018-12-23 修回日期:2019-02-14
基金项目: 国家自然科学基金资助项目(30801052、30671835、30500423、30200239)
作者简介:李文桂(1967-),男(汉族),博士,研究员.研究方向:病原微生物的分子生物学和分子免疫学.
更新日期/Last Update: 2019-07-02