[1]欧阳良良,袁育珺,梁晓君,等.25-羟维生素D3水平对ITP患儿外周血Th17/Treg相关细胞因子表达的影响[J].国外医学医学地理杂志,2019,(02):131-133,136.[doi:10.3969/j.issn.1001-8883.2019.02.009]
 OUYANG Liangliang,YUAN Yujun,LIANG Xiaojun,et al.To observe the effect of 25-hydroxyvitamin D3 level on the expression ofTh17/Treg-related cytokines in peripheral blood of children with ITP[J].Foreign Medical Sciences (Section of Medgeography),2019,(02):131-133,136.[doi:10.3969/j.issn.1001-8883.2019.02.009]
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25-羟维生素D3水平对ITP患儿外周血Th17/Treg相关细胞因子表达的影响()
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国外医学医学地理杂志[ISSN:1001-8883/CN:61-1102/R]

卷:
期数:
2019年02期
页码:
131-133,136
栏目:
基础医学
出版日期:
2019-07-02

文章信息/Info

Title:
To observe the effect of 25-hydroxyvitamin D3 level on the expression ofTh17/Treg-related cytokines in peripheral blood of children with ITP
作者:
欧阳良良1袁育珺1梁晓君1胡志坚1王文娟1苏占营2
(1.九江学院附属医院,2.九江妇女儿童医院,江西九江 332000)
Author(s):
OUYANG Liangliang1YUAN Yujun1LIANG Xiaojun1HU Zhijian1WANG Wenjuan1SU Zhanying2
(1.Affiliated Hospital of Jiujiang College,2.Jiujiang Women and Children Hospital,Jiujiang 332000,China)
关键词:
特发性血小板减少性紫癜 25-羟维生素D3 Th17 Treg 细胞因子
Keywords:
idiopathic thrombocytopenic purpura 25-hydroxyvitamin D3 Th17 treg cytokines
分类号:
R153.1
DOI:
10.3969/j.issn.1001-8883.2019.02.009
文献标志码:
A
摘要:
目的 探讨血清25-羟维生素D3水平对特发性血小板减少性紫癜(ITP)患儿外周血中Th17/Treg相关细胞因子的表达水平影响。方法 收集九江学院附属医院及九江市妇女儿童医院ITP患儿32例,测定血清25-羟维生素D3浓度,依据25-羟维生素D3浓度分为缺乏组(低于20 ng/mL),不足组(20~30 ng/mL)及正常组。同时以30名健康儿童为对照组,分别检测各组血清IL-17、IL-21、IL-10及TGF-β的表达水平。结果 ITP患儿组与正常组的年龄(t=1.989,P=0.682)、性别(χ2=1.013,P=0.859)无统计学意义。ITP患儿中维生素D3缺乏组和不足组的IL-10及TGF-β表达水平明显低于正常组和健康对照组(P<0.05),而IL-17及IL-21水平则显著高于ITP患儿的维生素D3正常组和健康对照组(P<0.05)。结论 血清25-羟维生素D3缺乏或减少与IL-17、IL-21、IL-10、TGF-β的表达水平密切相关,并对ITP患儿外周血Th17/Treg相关细胞因子表达起重要的调节作用。
Abstract:
Objective To investigate the effect of serum 25-hydroxyvitamin D3 level on the expression of Th17/Treg-related cytokines in peripheral blood of children with idiopathic thrombocytopenic purpura(ITP).Methods 32 children with ITP were collected from the affiliated Hospital of Jiujiang University and Jiujiang Women and Children Hospital.The serum concentrations of 25-hydroxyvitamin D3 were measured and divided into deficiency group(lower than 20 ng/mL)according to the concentration of 25-hydroxyvitamin D3.Deficiency group(between 20-30 ng/mL)and normal group.At the same time,30 healthy children were used as control,and serum I was detected in each group.The expression levels of L-17,IL-21,IL-10 and TGF-β were found.Results The age and sex of ITP group and normal group(t=1.989,P=0.682),(χ 2=1.013,respectively),the age of children and normal group(t=1.989,P=0.682),sex(χ 2=1.013),The expression levels of IL-10 and TGF-β in vitamin D3 deficiency group and deficiency group were significantly lower than those in normal group and healthy control group.The levels of IL-17 and IL-21 in ITP children were significantly higher than those in normal vitamin D3 group and healthy control group(P<0.05).Conclusion The deficiency or decrease of serum 25-hydroxyvitamin D3 is closely related to the expression of IL-17,IL-21,IL-10,TGF-β,and plays an important role in regulating the expression of Th17/Treg related cytokines in peripheral blood of children with ITP.

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备注/Memo

备注/Memo:
收稿日期:2019-01-08 修回日期:2019-02-25
基金项目:江西省卫计委基金资助项目(No.20174023)
通信作者:梁晓君,主管技师.从事血液学检验.
作者简介:欧阳良良(1982-),女(汉族),大学本科,副主任技师.从事血液学检验.
更新日期/Last Update: 2019-07-02