[1]张致英,张 寒,刘丽军,等.高原红细胞增多症相关蛋白因子和基因的研究进展[J].国外医学医学地理杂志,2019,(02):204-208.[doi:10.3969/j.issn.1001-8883.2019.02.030]
　ZHANG Zhiying,ZHANG Han,LIU Lijun,et al.Research progress on protein factors and genes of high altitude polycythemia[J].Foreign Medical Sciences (Section of Medgeography),2019,(02):204-208.[doi:10.3969/j.issn.1001-8883.2019.02.030]
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高原红细胞增多症相关蛋白因子和基因的研究进展()
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国外医学医学地理杂志[ISSN:1001-8883/CN:61-1102/R]

卷:
期数:
2019年02期
页码:
204-208
栏目:
综述与介评
出版日期:
2019-07-02

文章信息/Info

Title:
Research progress on protein factors and genes of high altitude polycythemia
作者:
张致英; 张 寒; 刘丽军; 赵锋仓; 康龙丽
(西藏民族大学高原病分子机制与干预研究省级重点实验室; 西藏民族大学环境与疾病相关基因研究高校重点实验室,陕西咸阳 712082)
Author(s):
ZHANG Zhiying; ZHANG Han; LIU Lijun; ZHAO Fengcang; KANG Longli
(Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region,School of Medicine,Xizang Minzu University; Key Laboratory of High Altitude Environment and Genes Related to Disease of TibetAutonomous Region; School of Medicine,Xizang Minzu University,Xianyang 712082,China)
关键词:
高原红细胞增多症;  蛋白因子;  基因
Keywords:
high altitude polycythemia;  protein factor;  genes
分类号:
R290
DOI:
10.3969/j.issn.1001-8883.2019.02.030
文献标志码:
A
摘要:
高原红细胞增多症(high altitude polycythemia,HAPC)是一种常见的慢性高原病,严重危害着高原地区人群的身体健康,至今病因未明。在过去几年中,遗传学和代谢组学研究为高原红细胞增多症的病理生理学提供了重要的见解。本文主要从遗传学和代谢角度综述红细胞增多症的可能潜在的病理生理机制,为探讨高原人群HAPC的发生机理和防治提供参考。
Abstract:
High altitude polycythemia(HAPC)is a common chronic altitude disease,which seriously affects the health of people in the plateau region.But in the past few years,genetic and metabolomic studies have provided important insights into the pathophysiology of altitude polycythemia.In this paper,the potential pathophysiological mechanisms of polycythemia were summarized from the perspective of genetics and metabolism with biomarkers as clues,so as to provide reference for the discussion of the occurrence mechanism and prevention and treatment of HAPC in plateau population.

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相似文献/References:

[1]刘丽军,张玉涛,张致英,等.高原红细胞增多症的研究进展[J].国外医学医学地理杂志,2018,39(03):267.[doi:10.3969/j.issn.1001-8883.2018.03.025]
　LIU Lijun,ZHANG Yutao,ZHANG Zhiying,et al.Research progress of high altitude polycythemia[J].Foreign Medical Sciences (Section of Medgeography),2018,39(02):267.[doi:10.3969/j.issn.1001-8883.2018.03.025]

备注/Memo

备注/Memo:
收稿日期:2018-12-15 修回日期:2019-01-25
基金项目:国家自然科学基金资助(No.81860329); 西藏自治区自然基金(No.2016ZR-MQ-06); 西藏自治区科技厅重点项目(No.XZ201801-GB03)
通信作者:康龙丽,教授,博士生导师.研究方向:环境与疾病相关机理研究.
作者简介:张致英(1986-),女(汉族),实验师.研究方向:环境与疾病相关机理研究.
更新日期/Last Update: 2019-07-02